DERL1 抗体 (N-Term)
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- 抗原 See all DERL1 抗体
- DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DERL1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 纯化方法
- Purified by antigen-specific affinity chromatography.
- 免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DERL1 (Derlin-1)
- Top Product
- Discover our top product DERL1 Primary Antibody
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anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 186-251) antibody
DERL1 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251), (C-Term) antibodyDERL1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22770 unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 111-220) antibodyDERL1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251) antibodyDERL1 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (C-Term) antibodyDERL1 适用: 人, 小鼠, 犬, 大鼠, 小鸡, Cow, 灵长类, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 222-251), (C-Term) antibodyDERL1 适用: 人, 小鼠 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 134-233) antibodyDERL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 182-251) antibodyDERL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- This antibody is stored in PBS, 50% glycerol
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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- 抗原
- DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
- 别名
- DERL1 (DERL1 产品)
- 别名
- CG10908 antibody, Dmel\\CG10908 antibody, DDBDRAFT_0188135 antibody, DDBDRAFT_0266772 antibody, DDB_0188135 antibody, DDB_0266772 antibody, MGC84200 antibody, wu:fb09d07 antibody, wu:fb94d05 antibody, wu:fj92g12 antibody, zgc:55637 antibody, 1110021N07Rik antibody, AI195141 antibody, AW551338 antibody, Derlin-1 antibody, derlin-1 antibody, DER-1 antibody, DER1 antibody, RGD1311835 antibody, DERLIN-1 antibody, F17A13.150 antibody, F17A13_150 antibody, Derlin-1 antibody, derlin-1 antibody, derlin-1.1 antibody, hypothetical protein antibody, Der1-like domain family, member 1 antibody, derlin 1 antibody, derlin 1 L homeolog antibody, DERLIN-1 antibody, Der-1 antibody, EDI_023440 antibody, PTRG_01331 antibody, derl1 antibody, DERL1 antibody, derl1.L antibody, Derl1 antibody, DER1 antibody
- 背景
- DERL1 (Derlin-1) is specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. DERL1 (Derlin-1) aarticipates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. DERL1 may act by forming a channel that allows the retro-translocation of misfolded proteins into the cytosol and transfer them to the ATPase VCP complex, which translocates and ubiquitinates misfolded proteins. In case of infection by the cytomegalovirus, it plays a central role in the export from the ER and subsequent degredation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. DERL1 (Derlin-1) interacts with VIMP/SELS and indirectly with VCP, suggesting that it forms a membrane complex with VIMP that serves as a receptor for VCP.
- 途径
- ER-Nucleus Signaling
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