DERL1 抗体 (N-Term)
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北京 101111
Quick Overview for DERL1 抗体 (N-Term) (ABIN965990)
抗原
See all DERL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- Purified by antigen-specific affinity chromatography.
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免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DERL1 (Derlin-1)
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anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251), (C-Term) antibody
DERL1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22770 unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 111-220) antibodyDERL1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251) antibodyDERL1 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 222-251), (C-Term) antibodyDERL1 适用: 人, 小鼠 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 200-251), (C-Term) antibodyDERL1 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- This antibody is stored in PBS, 50% glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
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别名
- DERL1
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背景
- DERL1 (Derlin-1) is specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. DERL1 (Derlin-1) aarticipates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. DERL1 may act by forming a channel that allows the retro-translocation of misfolded proteins into the cytosol and transfer them to the ATPase VCP complex, which translocates and ubiquitinates misfolded proteins. In case of infection by the cytomegalovirus, it plays a central role in the export from the ER and subsequent degredation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. DERL1 (Derlin-1) interacts with VIMP/SELS and indirectly with VCP, suggesting that it forms a membrane complex with VIMP that serves as a receptor for VCP.
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途径
- ER-Nucleus Signaling
抗原
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