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CLOCK 抗体 (N-Term)

Cited in 1 publication. This 兔 多克隆 anti-CLOCK antibody specifically detects CLOCK in IHC. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN965906
发货至: 中国
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Quick Overview for CLOCK 抗体 (N-Term) (ABIN965906)

抗原

See all CLOCK 抗体
CLOCK (Clock Homolog (Mouse) (CLOCK))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This CLOCK antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)
  • 抗原表位

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    N-Term

    纯化方法

    Purified by antigen-specific affinity chromatography.

    免疫原

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human CLOCK(Circadian locomoter output cycles protein kaput)
  • 应用备注

    ELISA, Western blotting: 1µg/ml for 2hrs.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    This antibody is stored in PBS, 50% glycerol

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • Moreira, Pedrazzoli, Dos Santos Coelho, Pradella-Hallinan, Lopes da Conceição, Pereira Peregrino, de Oliveira, Tufik: "Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients." in: Brain research. Molecular brain research, Vol. 140, Issue 1-2, pp. 150-4, (2005) (PubMed).

  • 抗原

    CLOCK (Clock Homolog (Mouse) (CLOCK))

    别名

    CLOCK

    背景

    CLOCK(Circadian locomoter output cycles protein kaput) is a circadian regulator that acts as a transcription factor. CLOCK-BMAL1 heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Mutant CLOCK and BMAL1 form hetereodimers that bind DNA, but fail to activate transcription. CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

    途径

    Regulation of Lipid Metabolism by PPARalpha, Photoperiodism
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