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CD247 抗体

This anti-CD247 antibody is a 小鼠 单克隆 antibody detecting CD247 in WB, ELISA, IHC, FACS 和 IF. Suitable for 人. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN965779
发货至: 中国

Quick Overview for CD247 抗体 (ABIN965779)

抗原

See all CD247 抗体
CD247 (CD247 Molecule (CD247))

适用

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宿主

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小鼠

克隆类型

  • 62
  • 23
单克隆

标记

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This CD247 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

克隆位点

4B10
  • 纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human CD247 expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    Immunofluorescence: 1/200 - 1/1000.
    Flow cytometry: 1/200 - 1/400.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.

    限制

    仅限研究用
  • 状态

    Liquid

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • de Bakker, van Bodegom, van de Poll, Boelen, Nat, Rozema, Aerts: "Is UV-B radiation affecting charophycean algae in shallow freshwater systems?" in: The New phytologist, Vol. 166, Issue 3, pp. 957-66, (2005) (PubMed).

    Nambiar, Fisher, Warke, Krishnan, Mitchell, Delaney, Tsokos: "Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus." in: Arthritis and rheumatism, Vol. 48, Issue 7, pp. 1948-55, (2003) (PubMed).

    Dumont, Blanchard, Di Bartolo, Lezot, Dufour, Jauliac, Hivroz: "TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 4, pp. 1705-12, (2002) (PubMed).

  • 抗原

    CD247 (CD247 Molecule (CD247))

    别名

    CD247

    背景

    The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
    Synonyms: T3Z, CD3H, CD3Q, CD3Z, TCRZ, CD3-ZETA, CD247

    分子量

    18kDa

    基因ID

    919

    途径

    TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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