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Aurora A 抗体

Cited in 2+ publications. The 小鼠 单克隆 anti-Aurora A antibody (Clone 1F8) (ABIN965625) specifically detects Aurora A in WB, ELISA, IF 和 FACS. The antibody is reactive with 人, 大鼠 和 猴 samples.
产品编号 ABIN965625
发货至: 中国
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Quick Overview for Aurora A 抗体 (ABIN965625)

抗原

See all Aurora A (AURKA) 抗体
Aurora A (AURKA) (Aurora Kinase A (AURKA))

适用

  • 127
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  • 2
  • 2
人, 大鼠, 猴

宿主

  • 122
  • 18
  • 1
  • 1
小鼠

克隆类型

  • 104
  • 37
单克隆

标记

  • 84
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  • 5
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  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
  • 1
This Aurora A antibody is un-conjugated

应用范围

  • 106
  • 50
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  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

克隆位点

1F8
  • 纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human AURKA expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    Western Bloting: 1/500 - 1/2000.
    Immunofluorescence: 1/200 - 1/1000.
    Flow cytometry: 1/200 - 1/400.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.

    限制

    仅限研究用
  • 状态

    Liquid

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • De Luca, Brunetto, Asteriti, Giubettini, Lavia, Guarguaglini: "Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity." in: Oncogene, Vol. 27, Issue 51, pp. 6539-49, (2008) (PubMed).

    Veerakumarasivam, Goldstein, Saeb-Parsy, Scott, Warren, Thorne, Mills, Venkitaraman, Neal, Kelly: "AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 22, pp. 3525-33, (2008) (PubMed).

  • 抗原

    Aurora A (AURKA) (Aurora Kinase A (AURKA))

    别名

    AURKA

    背景

    Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.
    Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
    Synonyms: AIK, ARK1, AURA, BTAK, STK6,

    分子量

    48kDa

    基因ID

    6790

    途径

    Cell Division Cycle, Asymmetric Protein Localization
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