PNPLA2 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for PNPLA2 抗体 (C-Term) (ABIN965617)
抗原
See all PNPLA2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
纯化方法
- Purified by antigen-specific affinity chromatography.
-
免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ATGL(adipose triglyceride lipase)
-
-
-
-
应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- This antibody is stored in PBS, 50% glycerol
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- PNPLA2 (Patatin-Like phospholipase Domain Containing 2 (PNPLA2))
-
别名
- ATGL (adipose triglyceride lipase)
-
背景
- ATGL(adipose triglyceride lipase) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. The adipose triglyceride lipase (ATGL) catalyzes the initial step in triglyceride hydrolysis. ATGL contains a patatin domain common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals. The iPLA2epsilon (adiponutrin), iPLA2zeta (TTS2.2), and iPLA2eta (GS2) are three novel TAG lipases/acylglycerol transacylases that likely participate in TAG hydrolysis and the acyl-CoA independent transacylation of acylglycerols
抗原
-