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- 抗原 See all CCL4 抗体
- CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))
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适用
- Pig
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CCL4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- This product was Protein-A purified from monospecific antiserum by chromatography. This antibody is specific for swine CCL4 protein. A BLAST analysis was used to suggest cross-reactivity with CCL4 from swine sources based on 100% homology with the immunizing sequence. Partial reactivity is expected against horse and panda CCL4 based on 98% homology, with bovine, dog, and rabbit based on 97% homology, macaque and feline based on 95%, with human and chimpanzee based on 94%, and with rat and opossum CCL4 based on 91% homology. Cross-reactivity with CCL4 from other sources has not been determined. The swine CCL4 sequence is also 86% homologous to swine CCL3L1.
- 产品特性
- In many species, both C-C chemokines macrophage inflammatory protein, or MIP-1 alpha (CCL3L1), and MIP-1 beta (CCL4) are structurally and functionally related CC chemokines. They are both potent chemoattractants for monocytes, which form an important component of the stroma of tumor tissue, and in humans may regulate tumor growth and associated inflammation. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. Both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes, but their effect on lymphocytes differ. MIP-1 alpha selectively attracts CD8+ lymphocytes, while MIP-1 beta selectively attracts CD4+ lymphocytes. They contain the four highly conserved cysteine residues present in CC chemokines. MIP-1 beta (CCL4) has specificity for CCR5 receptors. In humans, it is also a major HIV-suppressive factor produced by CD8+ T cells.
- 纯化方法
- purified
- 过滤
- Sterile filtered
- 免疫原
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This protein-A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with recombinant protein raised in yeast, corresponding to the 69 amino acids of the mature swine CCL4/MIP1ß protein.
Immunogen Type: RecombinantProtein - 亚型
- IgG
- Top Product
- Discover our top product CCL4 Primary Antibody
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anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) antibody
CCL4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) antibodyCCL4 适用: 人 WB, ELISA, IHC, ICC, Neut, FACS 宿主: 小鼠 Monoclonal 8F1C2 unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) antibodyCCL4 适用: 人 WB, ELISA, IHC, ICC, Neut, FACS 宿主: 小鼠 Monoclonal 7G7H9 unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 26-92) antibodyCCL4 适用: 人, 小鼠, 兔 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (Internal Region) antibodyCCL4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) antibodyCCL4 适用: 人 WB, ELISA, IHC (p), Func 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (C-Term) antibodyCCL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) antibodyCCL4 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 22-48) antibodyCCL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-84) antibodyCCL4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- This protein-A purified antibody is suitable for ELISA and Western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 7.8 kDa in size corresponding to swine CCL4 protein by western blotting in the appropriate cell lysate or extract.
- 说明
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Gene Name: CCL4
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 100 µL
- 浓度
- 1.0 mg/mL
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
- 有效期
- 12 months
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- 抗原
- CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))
- 别名
- MIP 1 beta (CCL4 产品)
- 别名
- ACT2 antibody, AT744.1 antibody, G-26 antibody, HC21 antibody, LAG-1 antibody, LAG1 antibody, MIP-1-beta antibody, MIP1B antibody, MIP1B1 antibody, SCYA2 antibody, SCYA4 antibody, CCL4 antibody, K203 antibody, Mip1-b antibody, Scya4 antibody, MIP-1beta antibody, MIP-1BETA antibody, MIP1b antibody, SCY4A antibody, Act-2 antibody, MIP-1B antibody, Mip1b antibody, ACT-2 antibody, AT744.2 antibody, CCL4L antibody, SCYA4L antibody, SCYA4L1 antibody, SCYA4L2 antibody, C-C motif chemokine ligand 4 antibody, chemokine (C-C motif) ligand 4 antibody, chemokine (C-C motif) ligand 4-like 1 antibody, C-C motif chemokine ligand 4 like 1 antibody, CCL4 antibody, Ccl4 antibody, CCL4L1 antibody
- 背景
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In many species, both C-C chemokines macrophage inflammatory protein, or MIP-1 alpha (CCL3L1), and MIP-1 beta (CCL4) are structurally and functionally related CC chemokines. They are both potent chemoattractants for monocytes, which form an important component of the stroma of tumor tissue, and in humans may regulate tumor growth and associated inflammation. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. Both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes, but their effect on lymphocytes differ. MIP-1 alpha selectively attracts CD8+ lymphocytes, while MIP-1 beta selectively attracts CD4+ lymphocytes. They contain the four highly conserved cysteine residues present in CC chemokines. MIP-1 beta (CCL4) has specificity for CCR5 receptors. In humans, it is also a major HIV-suppressive factor produced by CD8+ T cells.
Synonyms: CCL4, C-C motif chemokine 4, Small-inducible cytokine A4, Macrophage inflammatory protein 1-beta, MIP-1-beta, ACT-2, MIP-1ß - 基因ID
- 396668
- UniProt
- Q711P4
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