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- 抗原 See all NEDD1 抗体
- NEDD1 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (NEDD1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NEDD1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- This product was adsorbed against GST from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with endogenous Nedd1 protein. A BLAST analysis was used to suggest reactivity with Nedd1 from human, chimpanzee, macaque, marmoset, cattle, rat, and mouse based on a 100% homology with the immunizing sequence. Expect partial reactivity with Nedd1 from turkey, chicken, salmon, and Danio based on a 91% homology with the immunizing sequence. Cross-reactivity with Nedd1 from other sources has not been determined.
- 产品特性
- This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Microtubules are polymers of tubulin, which exist as heterodimers of alpha-tubulin and beta-tubulin. NEDD1 (neural precursor expressed, developmentally down-regulated protein1, also called GCP-WD) is a centrosomal protein that in mammals associates with the gamma-tubulin ring complex (gamma-TuRC). gamma-TuRC is critical for initiation, or nucleation, of the microtubule assembly. In association with this complex, NEDD1 plays an important role in targeting the gamma-TuRC complex to the site of microtubule nucleation and to the mitotic spindle. These events are essential for proper bipolar spindle formation and mitotic progression. Given the casual link between improper spindle function and tumorigenesis, characterization of Nedd1 function will be important to better understand various mechanisms underlying mitotic regulation, chromosome segregation, and cancer development.
- 过滤
- Sterile filtered
- 免疫原
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Anti-NEDD1 was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to the 343-667 region of human Nedd1.
Immunogen Type: RecombinantProtein - Top Product
- Discover our top product NEDD1 Primary Antibody
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anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (NEDD1) (AA 561-660) antibody
NEDD1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 7D10 unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (NEDD1) (AA 411-660) antibodyNEDD1 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (NEDD1) (AA 411-660) antibodyNEDD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (NEDD1) antibodyNEDD1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (NEDD1) (Internal Region) antibodyVerified NEDD1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (NEDD1) (N-Term) antibodyNEDD1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, Bat WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- This antiserum has been tested for use in ELISA and western blotting using a recombinant truncated Nedd1 protein. Specific conditions for reactivity and detection of Nedd1 should be optimized by the end user. Expect a band approximately ~73 kDa in size corresponding to Nedd1 by western blotting in the appropriate cell lysate or extract.
- 说明
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Gene Name: NEDD1
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 40 mg/mL
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
- 有效期
- 3 months
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- 抗原
- NEDD1 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (NEDD1))
- 别名
- NEDD1 (NEDD1 产品)
- 别名
- MGC81767 antibody, MGC145237 antibody, GCP-WD antibody, TUBGCP7 antibody, neural precursor cell expressed, developmentally down-regulated 1 L homeolog antibody, neural precursor cell expressed, developmentally down-regulated 1 antibody, cilia and flagella associated protein 54 antibody, neural precursor cell expressed, developmentally down-regulated gene 1 antibody, nedd1.L antibody, nedd1 antibody, CFAP54 antibody, NEDD1 antibody, Nedd1 antibody
- 背景
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This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Microtubules are polymers of tubulin, which exist as heterodimers of alpha-tubulin and beta-tubulin. NEDD1 (neural precursor expressed, developmentally down-regulated protein1; also called GCP-WD) is a centrosomal protein that in mammals associates with the gamma-tubulin ring complex (γ-TuRC). γ-TuRC is critical for initiation, or nucleation, of the microtubule assembly. In association with this complex, NEDD1 plays an important role in targeting the γ-TuRC complex to the site of microtubule nucleation and to the mitotic spindle. These events are essential for proper bipolar spindle formation and mitotic progression. Given the casual link between improper spindle function and tumorigenesis, characterization of Nedd1 function will be important to better understand various mechanisms underlying mitotic regulation, chromosome segregation, and cancer development.
Synonyms: GCP-WD, Neural precursor cell expressed developmentally down-regulated protein 1 - 基因ID
- 121441
- NCBI登录号
- NP_001128647
- UniProt
- Q8NHV4
- 途径
- M Phase
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