Melanoma Associated Antigen 抗体
This anti-Melanoma Associated Antigen antibody is a 小鼠 单克隆 antibody detecting Melanoma Associated Antigen in IHC, ELISA, IHC (fro), IF, IHC (p) 和 IP. Suitable for 人.
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Quick Overview for Melanoma Associated Antigen 抗体 (ABIN959527)
抗原
Melanoma Associated Antigen (MAGE)
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This Melanoma Associated Antigen antibody is un-conjugated
应用范围
Immunohistochemistry (IHC), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
克隆位点
NKI-C3
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特异性
- Used for diagnostic by staining of lysosomes/melanosomes. Directed against a predominantly intracellular protein of human melanoma cells. The antigen is abundantly present in malignant melanomas, nevocellular nevi, and neuroendocrine tumors, whereas it has not been detectable in most other tissues. The antigen recognized is a glycoprotein which appears as a broad band in SDS-PAGE. The antigen was shown to consist of a single protein backbone to which two or three V-linked glycans were added cotranslationally. Extensive further heterogeneity was generated in the Colgi compartmen and was shown to be dependent on the presence of complex type sugars. Although the antigen is associated with melanomas, it was not codistributed with the tyrosinase activity associated with melanogenesis. The antigen did show codistribution with cathepsin D, which is a marker for lysosomal functions.This antibody was originally described as a marker for melanoma. Recently, it resurfaced as a marker to separate cellular neurothekeoma from other dermal tumors in the differential diagnosis.
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纯化方法
- Purified
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免疫原
- Melanoma-associated antigen
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亚型
- IgG1
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应用备注
- Approved: ELISA, IF, IHC, IHC-Fr, IHC-P (10 μg/mL), IP
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说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- avoid freeze thaw cycles. Store undiluted.
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储存条件
- 4 °C,-20 °C
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储存方法
- Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.
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- Melanoma Associated Antigen (MAGE)
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别名
- Melanoma-Associated Antigen
抗原
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