SAR1B 抗体 (Middle Region)
Quick Overview for SAR1B 抗体 (Middle Region) (ABIN954670)
抗原
See all SAR1B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 96-124, Middle Region
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特异性
- Recognizes SAR1B (Center).
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纯化方法
- Protein A column followed by peptide Affinity purification
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免疫原
- KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of Human SAR1B Genename: SAR1B
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亚型
- Ig Fraction
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- SAR1B (SAR1 Homolog B (SAR1B))
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别名
- SAR1B
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背景
- SAR1B belongs to the small GTPase superfamily, SAR1 family. It is involved in transport from the endoplasmic reticulum to the Golgi apparatus and is activated by the guanine nucleotide exchange factor PREB. SAR1B is involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The conditions are characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Cellular localization: Endoplasmic reticulum membrane, Peripheral membrane protein. Golgi apparatus, Golgi stack membrane, Peripheral membrane protein. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.Synonyms: GTBPB, GTP-binding protein SAR1b, SAR1B, SARA2, SARB
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基因ID
- 51128
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NCBI登录号
- NP_001028675
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途径
- Lipid Metabolism
抗原
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