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PAX5 抗体 (Middle Region)

This anti-PAX5 antibody is a Rabbit Polyclonal antibody detecting PAX5 in WB, EIA. Suitable for Human.
产品编号 ABIN954009
发货至: 中国

Quick Overview for PAX5 抗体 (Middle Region) (ABIN954009)

抗原

See all PAX5 抗体
PAX5 (Paired Box 5 (PAX5))

适用

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宿主

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克隆类型

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多克隆

标记

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This PAX5 antibody is un-conjugated

应用范围

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • 抗原表位

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    AA 185-215, Middle Region

    特异性

    This antibody reacts to PAX5.

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Affinity chromatography on Protein A

    免疫原

    KLH conjugated synthetic peptide between 185-215 amino acids from the Central region of human PAX5

    亚型

    Ig Fraction
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.25 mg/mL

    缓冲液

    PBS, 0.09 % (W/V) sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    PAX5 (Paired Box 5 (PAX5))

    别名

    PAX5

    背景

    This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.Synonyms: B-cell-specific transcription factor, BSAP, Paired box protein Pax-5, Pax-5

    分子量

    42149 Da

    基因ID

    5079

    NCBI登录号

    NP_057953
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