NPW is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq].Synonyms: 23, 30, Neuropeptide W, Neuropeptide W-23, Neuropeptide W-30, PP, PPL8, Preproprotein L8, hL8, hL8C, hPPL8