MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].Synonyms: MAD1-like 1, Mitotic arrest deficient-like protein 1, Mitotic checkpoint MAD1 protein homolog, Mitotic spindle assembly checkpoint protein MAD1, Tax-binding protein 181