KDM3B 抗体 (Middle Region)
Our Local Distributor
北京 101111
Quick Overview for KDM3B 抗体 (Middle Region) (ABIN952970)
抗原
See all KDM3B 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 876-905, Middle Region
-
特异性
- This antibody recognizes Human JMJD1B / KDM3B (Center).
-
纯化方法
- Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
-
免疫原
- KLH conjugated synthetic peptide between 876-905 amino acids from the Central region of human JHDM2b Genename: KDM3B
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.25 mg/mL
-
缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))
-
别名
- JMJD1B / KDM3B
-
背景
- Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.Synonyms: 5qNCA, C5orf7, JHDM2B, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, KIAA1082, Lysine-specific demethylase 3B, Nuclear protein 5qNCA
-
分子量
- 84kd
-
基因ID
- 51780
-
NCBI登录号
- NP_057688
-
途径
- Warburg Effect
抗原
-