Anti-human Glycophorin A (GpA) Polyclonal Antibody targets the human Glycophorin A protein. This polyclonal antibody recognizes various epitopes on the GpA protein. The 23 residue hydrophobic transmembrane domain has been shown to mediate non-covalent dimerization of the protein under conditions of SDS page (and in other detergents). We also sell a FITC conjugated version of this antibody (AP31671FC-N).
纯化方法
Affinity chromatography on Protein G
免疫原
Human Glycophorin A transmembrane protein Donor: Rabbit serum
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
浓度
1,0 mg/mL
缓冲液
PBS containing 0.02 % sodium azide (NaN3) as preservative
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原
CD235a/GYPA (GYPA)
(Glycophorin A (GYPA))
别名
CD235a / GYPA
背景
This 131 amino acid, 36 KDa, transmembrane sialoglycoprotein spans the membrane of erythrocytes once. GpA presents its N terminus at the extracellular surface of the human red blood cell, has a single transmembrane domain and an internal cytoplasmic C terminus. GpA contributes to the expression of blood group antigen M and N specificities, which work to prevent red blood cell aggregation in circulation. Studies show that GpA is expressed early on the cell surface during erythropoiesis as pluripotent stem cells are recruited to differentiate into erythrocytes. This makes GpA a useful marker for studying the developmental biology of hematopoietic progenitor cells.Synonyms: GPA, Glycophorin-A, MN sialoglycoprotein, PAS-2, Sialoglycoprotein alpha