SMPD1 抗体
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北京 101111
Quick Overview for SMPD1 抗体 (ABIN950236)
抗原
See all SMPD1 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Purified
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免疫原
- Synthetic peptide derived from human acid sphingomyelinase protein.
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anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 391-419), (C-Term) antibody
SMPD1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB31029 unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 319-579) antibodySMPD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 70-340) antibodySMPD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 1-364) antibodySMPD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H2 unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 391-419), (C-Term) antibodySMPD1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 201-300) antibodySMPD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 396-445) antibodySMPD1 适用: 人, 小鼠, 大鼠, Cow, 绵羊, 犬, 马, 兔, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 391-419) antibodySMPD1 适用: 人 WB, IHC, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS, pH 7.4 containing 0.08 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Ship at ambient temperature, freeze upon arrival. Product should be stored (in aliquots) at -20 °C.
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- SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))
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别名
- Acid Sphingomyelinase
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背景
- Human acid sphingomyelinase (sphingomyelin phosphodiesterase, ASM) is the lysosomal enzyme responsible for the hydrolysis of sphingomyelin to ceramide and phosphocholine. Converts sphingomyelin to ceramide. aSM also has phospholipase C activities toward 1,2-diacylglycerol-phosphocholine and 1,2-diacylglycerol-phosphoglycerol. The enzyme is a membrane-associated glycoprotein with a pH optimum of about 4.5 and a subunit molecular mass of about 72 kDa. In addition AtoS M, two other sphingomyelinases have been identified in man, a Mg2+- dependent neutral sphingomyelinase found primarily in brain and a Zn2+-dependent acid sphingomyelinase found primarily in serum. Although it is likely that the acid and neutral sphingomyelinases are coded by different genes, the molecular genetic relationship of these three biochemically distinct sphingomyelinases has not been determined. Understanding the role of these sphingomyelinases in the hydrolysis of sphingomyelin to ceramide will be an important step in the understanding of ceramide as it is further hydrolyzed to sphingosine, a neutral phospholipid which has been implicated in the regulation of protein kinase C-mediated signal transduction. Inherited deficiencies of ASM have been reported in man, deficient ASM activity results in the two major subtypes of Niemann-Pick disease (NPD).Synonyms: ASM, ASM-1, Acid Sphingomyelinase, SMPD1, Sphingomyelin Phosphodiesterase, aSMase
抗原
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