B-Cell Linker 抗体 (AA 171-356)
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北京 101111
Quick Overview for B-Cell Linker 抗体 (AA 171-356) (ABIN94495)
抗原
See all B-Cell Linker (BLNK) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 171-356
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原理
- Anti-Ms Blnk Purified
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交叉反应 (详细)
- Mouse
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产品特性
- The polyclonal antibody reacts with mouse SLP65 / BLNK, a cytosolic adaptor protein identified as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE (alternatively spliced forms of human SLP65).
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- A fusion protein representing amino acids 171-356 of human BLNK.
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应用备注
- Western blotting: Reducing conditions.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- B-Cell Linker (BLNK)
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别名
- Blnk
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背景
- B cell linkerprovided,SLP65 / BLNK (SH2 domain-containing leukocyte-specific phosphoprotein of 65 kDa, B cell linker protein), also known as BASH, is an adaptor protein that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). Phosphorylated by Syk tyrosine kinase, SLP65 serves as a scaffold for Btk tyrosine kinase, Vav1 guanine nucleotide exchange factor, phospholipase C gamma2, as well as Grb2 and Nck adaptor proteins, thus represents a central linker protein that bridges the BCR-associated kinases with a multitude of signaling pathways.,SLP65, BASH, Ly57
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基因ID
- 29760
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UniProt
- Q8WV28
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途径
- BCR Signaling
抗原
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