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TNC 抗体

This anti-TNC antibody is a 小鼠 单克隆 antibody detecting TNC in WB, IP 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN94480
发货至: 中国

Quick Overview for TNC 抗体 (ABIN94480)

抗原

See all TNC 抗体
TNC (Tenascin C (TNC))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This TNC antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

T2H5
  • 原理

    Anti-Hu Tenascin C Purified

    特异性

    The antibody T2H5 recognizes tenascin C, a large hexameric extracellular matrix glycoprotein.

    交叉反应 (详细)

    Other not tested, Human

    纯化方法

    Purified by protein-A affinity chromatography.

    纯度

    > 95 % (by SDS-PAGE)

    免疫原

    Protein preparation from a homogenate of a human mammary tumour specimen.

    亚型

    IgG1
  • 应用备注

    Immunohistochemistry (paraffin sections): Immunohistochemical detection of tenascin is valuable for studies of tissue differentiation and tumour growth. The antibody T2H5 is excellent for staining of paraffin-embedded tissue sections. Heat-mediated antigen retrieval in citrate buffer.
    Western blotting: Recommended dilution: 1-2 μg/mL.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • Gulubova: "Immunohistochemical localization of collagen type III and type IV, laminin, tenascin and alpha-smooth muscle actin (alphaSMA) in the human liver in peliosis." in: Pathology, research and practice, Vol. 198, Issue 12, pp. 803-12, (2003) (PubMed).

    Faustino, van Garderen, Schalken, Nederbragt: "Tenascin expression in normal, hyperplastic, dysplastic and neoplastic canine mammary tissues." in: Journal of comparative pathology, Vol. 126, Issue 1, pp. 1-8, (2002) (PubMed).

    Ioachim, Charchanti, Briasoulis, Karavasilis, Tsanou, Arvanitis, Agnantis, Pavlidis et al.: "Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and ..." in: European journal of cancer (Oxford, England : 1990), Vol. 38, Issue 18, pp. 2362-70, (2002) (PubMed).

    Tökés, Hortoványi, Csordás, Kulka, Mózes, Hatalyák, Kádár: "Immunohistochemical localisation of tenascin in invasive ductal carcinoma of the breast." in: Anticancer research, Vol. 19, Issue 1A, pp. 175-9, (1999) (PubMed).

  • 抗原

    TNC (Tenascin C (TNC))

    别名

    Tenascin C

    背景

    Tenascin C,Tenascin C is an approximately 250 kDa extracellular matrix glycoprotein with important roles in the nervous system, as it promotes correct migration of growing axons during development and during neuronal regeneration. It is also involved in synaptic plasticity. Ligands of tenascin C are integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3, and alpha-V/beta-6. Similarly to neural cells, it also stimulates angiogenesis by promoting elongation and migration of endothelial cells.,TNC, Hexabrachion, Cytotactin, Neuronectin

    基因ID

    3371

    UniProt

    P24821

    途径

    Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development
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