LYN 抗体 (AA 8-238)
(3 references)Quick Overview for LYN 抗体 (AA 8-238) (ABIN94427)
抗原
See all LYN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 8-238
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原理
- Anti-LYN Purified
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特异性
- The antibody LYN-01 reacts with Lyn (p56/p53), a non-receptor Src-family tyrosine kinase expressed in hematopoietic tissues (intracellular antigen).
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交叉反应 （详细）
- Mouse, Human, Rat
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).
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亚型
- IgG1
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anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (pTyr507) antibody
LYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (C-Term) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (Center) antibodyLYN 适用: 人 WB, IP, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 229-263) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 32-62) antibodyLYN 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 470-501) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (pTyr397) antibodyLYN 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (pTyr508) antibodyLYN 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 犬, 豚鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 229-263) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB50588 unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 39-58) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, IHC, IP, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
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应用备注
- Western blotting: Recommended dilution: 1-2 μg/mL.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Role of Src kinases in mobilization of glycosylphosphatidylinositol-anchored decay-accelerating factor by Dr fimbria-positive adhering bacteria." in: Infection and immunity, Vol. 79, Issue 7, pp. 2519-34, (2011) (PubMed).
: "Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors." in: European journal of immunology, Vol. 27, Issue 1, pp. 321-8, (1997) (PubMed).
: "Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains." in: Immunology, Vol. 87, Issue 1, pp. 141-8, (1996) (PubMed).
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: "Role of Src kinases in mobilization of glycosylphosphatidylinositol-anchored decay-accelerating factor by Dr fimbria-positive adhering bacteria." in: Infection and immunity, Vol. 79, Issue 7, pp. 2519-34, (2011) (PubMed).
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- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
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别名
- LYN
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背景
- LYN proto-oncogene, Src family tyrosine kinase,Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.,JTK8, p56Lyn, p53Lyn
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基因ID
- 4067
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UniProt
- P07948
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途径
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
抗原
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