HIV-1/2 Protease (HIV-1/2 p10) 抗体
Cited in 4+ publications. This anti-HIV-1/2 Protease antibody is a 小鼠 单克隆 antibody detecting HIV-1/2 Protease in ELISA 和 WB. Suitable for Human Immunodeficiency Virus (HIV).
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(4 references)
产品编号 ABIN94325
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Quick Overview for HIV-1/2 Protease (HIV-1/2 p10) 抗体 (ABIN94325)
抗原
HIV-1/2 Protease (HIV-1/2 p10)
适用
Human Immunodeficiency Virus (HIV)
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
ELISA, Western Blotting (WB)
克隆位点
1696
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原理
- Anti-HIV-1/HIV-2 protease Purified
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特异性
- The antibody 1696 recognizes free N-terminus of mature HIV protease (HIV-1 and HIV-2), an enzyme that hydrolyzes polyproteins of HIV viruses into functional proteins. The antibody 1696 does not react with the precursor.
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交叉反应 （详细）
- HIV
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Bacterially expressed full-length HIV-1 protease
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亚型
- IgG1
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anti-HIV-1/2 Protease (HIV-1/2 p10) antibody
HIV-1/2 p10 适用: Human Immunodeficiency Virus (HIV) ELISA, WB, Func 宿主: 小鼠 Monoclonal 1696 unconjugated
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应用备注
- Western blotting: Recommended dilution: 0.5 μg/mL.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Increased expression and immunogenicity of HIV-1 protease following inactivation of the enzymatic activity." in: Vaccine, Vol. 29, Issue 4, pp. 839-48, (2011) (PubMed).
: "Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies." in: Antiviral research, Vol. 78, Issue 3, pp. 275-7, (2008) (PubMed).
: "Diversification and specialization of HIV protease function during in vitro evolution." in: Molecular biology and evolution, Vol. 23, Issue 4, pp. 764-72, (2006) (PubMed).
: "Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody." in: Protein science : a publication of the Protein Society, Vol. 8, Issue 12, pp. 2686-96, (2000) (PubMed).
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: "Increased expression and immunogenicity of HIV-1 protease following inactivation of the enzymatic activity." in: Vaccine, Vol. 29, Issue 4, pp. 839-48, (2011) (PubMed).
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- HIV-1/2 Protease (HIV-1/2 p10)
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别名
- HIV-1/HIV-2 protease
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物质类
- Viral Protein
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背景
- The HIV protease (PR) hydrolyzes polyproteins of HIV virus into functional protein products that are essential for its assembly and subsequent activity. This maturation process occurs as the virion buds from the host cell. HIV protease inhibitors are used in the treatment of patients with AIDS and were considered the first breakthrough in over a decade of AIDS research. HIV protease inhibitors can lower the viral load carried by AIDS patents.,HIV-1 PR, HIV-2 PR
抗原
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