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CD72 抗体

CD72 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal 3F3 unconjugated
产品编号 ABIN94227
发货至: 中国
  • 抗原 See all CD72 抗体
    CD72 (CD72 Molecule (CD72))
    适用
    • 45
    • 19
    • 1
    宿主
    • 37
    • 19
    • 1
    小鼠
    克隆类型
    • 37
    • 20
    单克隆
    标记
    • 25
    • 7
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD72 antibody is un-conjugated
    应用范围
    • 29
    • 24
    • 21
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    特异性
    The mouse monoclonal antibody 3F3 recognizes an extracellular epitope of CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.
    交叉反应 (详细)
    Human
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Normal human lymphocytes from a lymph node.
    克隆位点
    3F3
    亚型
    IgG2b
  • 应用备注
    Flow cytometry: Recommended dilution: 1 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Mizrahi, Markel, Porgador, Bushkin, Mandelboim: "CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." in: PLoS ONE, Vol. 2, Issue 9, pp. e818, (2007) (PubMed).

  • 抗原
    CD72 (CD72 Molecule (CD72))
    别名
    CD72 (CD72 产品)
    别名
    CD72c antibody, Ly-19 antibody, Ly-32 antibody, Ly-m19 antibody, Lyb-2 antibody, CD72b antibody, LYB2 antibody, CD72 antigen antibody, CD72 molecule antibody, Cd72 antibody, CD72 antibody
    背景
    CD72 Molecule,CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.,LYB2
    基因ID
    971
    UniProt
    P21854
    途径
    BCR Signaling
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