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CD7 抗体

This anti-CD7 antibody is a 小鼠 单克隆 antibody detecting CD7 in FACS, WB, IP 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN94218
发货至: 中国

Quick Overview for CD7 抗体 (ABIN94218)

抗原

See all CD7 抗体
CD7

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD7 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

MEM-186
  • 原理

    Anti-Hu CD7 Purified

    特异性

    The antibody MEM-186 reacts with an extracellular epitope of CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia.

    交叉反应 (详细)

    Human

    纯化方法

    Purified by protein-A affinity chromatography.

    纯度

    > 95 % (by SDS-PAGE)

    免疫原

    Human acute myelogenous leukaemia cell line KG-1.

    亚型

    IgG1 kappa
  • 应用备注

    Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL, positive tissue: spleen.
    Flow cytometry: Recommended dilution: 2 μg/mL.
    Western blotting: Non-reducing conditions.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • Rappl, Riet, Awerkiew, Schmidt, Hombach, Pfister, Abken: "The CD3-zeta chimeric antigen receptor overcomes TCR Hypo-responsiveness of human terminal late-stage T cells." in: PLoS ONE, Vol. 7, Issue 1, pp. e30713, (2012) (PubMed).

  • 抗原

    CD7

    别名

    CD7

    背景

    CD7 Molecule,CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.,GP40, TLA, TP41, LEU-9

    基因ID

    924

    UniProt

    P09564

    途径

    Cell-Cell Junction Organization
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