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CD41, CD61 抗体

适用: 人, Cow FACS, IP, ELISA, ICC 宿主: 小鼠 Monoclonal IVA30 unconjugated
产品编号 ABIN94110
发货至: 中国
  • 抗原 See all CD41, CD61 抗体
    CD41, CD61 (CD41,CD61)
    适用
    • 12
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, Cow
    宿主
    • 20
    小鼠
    克隆类型
    • 20
    单克隆
    标记
    • 9
    • 4
    • 4
    • 2
    • 1
    This CD41, CD61 antibody is un-conjugated
    应用范围
    • 16
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Immunocytochemistry (ICC)
    特异性
    The antibody IVA30 reacts with an extracellular epitope on CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes, the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT). This antibody crossreacts with human platelets.
    交叉反应 (详细)
    Human, Bovine
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Bovine trombocytes.
    克隆位点
    IVA30
    亚型
    IgG2
  • 应用备注
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • "Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 213-468, (1997) (PubMed).

    Mateo, Perez de la Lastra, Moreno, Dusinsky, Bilka, Simon, Horovska, Llanes: "Biochemical characterization of antigens detected with anti-platelet monoclonal antibodies." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 363-70, (1997) (PubMed).

    Mateo, Pintado, Perez de la Lastra, Dusinsky, Simon, Naessens, Llanes: "Ruminant cluster CD41/CD61." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 251-3, (1997) (PubMed).

    Naessens, Howard, Hopkins: "Nomenclature and characterization of leukocyte differentiation antigens in ruminants." in: Immunology today, Vol. 18, Issue 8, pp. 365-8, (1997) (PubMed).

    Simon, Dusinsky, Horovska, Bilka, Hluchy: "Immunohistochemical reactivity of anti-platelet monoclonal antibodies." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 377-82, (1997) (PubMed).

  • 抗原
    CD41, CD61 (CD41,CD61)
    Abstract
    CD41, CD61 产品
    背景
    CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.,platelet GPIIb, Integrin alpha-IIb, GPalpha IIb, GPIIb, GT, GP3A, platelet GPIIIa
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