CD41, CD61 抗体
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Quick Overview for CD41, CD61 抗体 (ABIN94110)
抗原
See all CD41, CD61 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Bov CD41/CD61 Purified
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特异性
- The antibody IVA30 reacts with an extracellular epitope on CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes, the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT). This antibody crossreacts with human platelets.
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交叉反应 （详细）
- Human, Bovine
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Bovine trombocytes.
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亚型
- IgG2
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anti-CD41,CD61 (PAC-1 epitope) antibody
适用: 人 FACS, IP, ICC 宿主: 小鼠 Monoclonal PAC-1 unconjugated
anti-CD41,CD61 antibody适用: Cow, 绵羊, Cat, 犬, 山羊, 马, 兔 FACS, IP, ELISA 宿主: 小鼠 Monoclonal CO-35E4 unconjugated
anti-CD41,CD61 antibody (PE)适用: 小鸡 FACS 宿主: 小鼠 Monoclonal 11C3 PE
anti-CD41,CD61 (PAC-1 epitope) antibody (PE)适用: 人 FACS 宿主: 小鼠 Monoclonal PAC-1 PE
anti-CD41,CD61 (PAC-1 epitope) antibody (PerCP)适用: 人 FACS 宿主: 小鼠 Monoclonal PAC-1 PerCP
anti-CD41,CD61 (PAC-1 epitope) antibody (FITC)适用: 人 FACS 宿主: 小鼠 Monoclonal PAC-1 FITC
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应用备注
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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"Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 213-468, (1997) (PubMed).
: "Biochemical characterization of antigens detected with anti-platelet monoclonal antibodies." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 363-70, (1997) (PubMed).
: "Ruminant cluster CD41/CD61." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 251-3, (1997) (PubMed).
: "Nomenclature and characterization of leukocyte differentiation antigens in ruminants." in: Immunology today, Vol. 18, Issue 8, pp. 365-8, (1997) (PubMed).
: "Immunohistochemical reactivity of anti-platelet monoclonal antibodies." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 377-82, (1997) (PubMed).
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"Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995." in: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 213-468, (1997) (PubMed).
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- CD41, CD61 (CD41,CD61)
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背景
- CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.,platelet GPIIb, Integrin alpha-IIb, GPalpha IIb, GPIIb, GT, GP3A, platelet GPIIIa
抗原
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