CD22 抗体 (Biotin)
Quick Overview for CD22 抗体 (Biotin) (ABIN94035)
抗原
See all CD22 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD22 Biotin
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特异性
- The antibody MEM-01 reacts with an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes, it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes. The antibody MEM-01 cross-blocks the antibody OTH228 that recognizes uniquely epitope "E", it does not cross-block antibodies RFB-4, CLB22/1 and CLB-BLy1.
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交叉反应 （详细）
- Human, Non-Human Primates
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纯化方法
- Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
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免疫原
- Raji Burkitt's lymphoma cell line
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亚型
- IgG1
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anti-CD22 Molecule (CD22) (AA 621-725) antibody
CD22 适用: 人 FACS, WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2H1C4 unconjugated
anti-CD22 Molecule (CD22) (AA 52-178) antibodyCD22 适用: 人 FACS, WB, ELISA, IHC, IF, Coat, StM 宿主: 小鼠 Monoclonal BLCAM-1795 unconjugated
anti-CD22 Molecule (CD22) (AA 621-725) antibodyCD22 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 1A3A11 unconjugated
anti-CD22 Molecule (CD22) (AA 52-178) antibodyCD22 适用: 人 FACS, WB, ELISA, IHC, IF, Coat 宿主: 小鼠 Monoclonal BLCAM-1796 unconjugated
anti-CD22 Molecule (CD22) antibodyCD22 适用: 人, Non-Human Primate FACS, WB, IP 宿主: 小鼠 Monoclonal MEM-01 unconjugated
anti-CD22 Molecule (CD22) antibodyCD22 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4C3 unconjugated
anti-CD22 Molecule (CD22) (AA 20-687) antibodyCD22 适用: 人 FACS, WB, ELISA, IF, IP 宿主: 兔 Monoclonal DM13 unconjugated
anti-CD22 Molecule (CD22) antibody (PE)CD22 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-01 PE
anti-CD22 Molecule (CD22) antibody (FITC)CD22 适用: 人 FACS 宿主: 小鼠 Monoclonal IS7 FITC
anti-CD22 Molecule (CD22) (AA 52-178) antibodyCD22 适用: 人 IHC 宿主: 兔 Monoclonal MSVA-022R unconjugated Recombinant Antibody
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应用备注
- Flow cytometry: Recommended dilution: 1-3 μg/mL.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
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Do not freeze.
Avoid prolonged exposure to light. -
储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- CD22 (CD22 Molecule (CD22))
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别名
- CD22
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背景
- CD22 Molecule,CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.,SIGLEC2, SIGLEC-2
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基因ID
- 933
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UniProt
- P20273
抗原
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