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Endoglin 抗体

This anti-Endoglin antibody is a 小鼠 单克隆 antibody detecting Endoglin in WB, FACS, IP 和 MS. Suitable for 人 和 大鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN93939
发货至: 中国

Quick Overview for Endoglin 抗体 (ABIN93939)

抗原

See all Endoglin (ENG) 抗体
Endoglin (ENG)

适用

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人, 大鼠

宿主

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小鼠

克隆类型

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单克隆

标记

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This Endoglin antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Mass Spectrometry (MS)

克隆位点

MEM-226
  • 原理

    Anti-Hu CD105 Purified

    特异性

    The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

    交叉反应 (详细)

    Human, Rat

    纯化方法

    Purified by protein-A affinity chromatography.

    纯度

    > 95 % (by SDS-PAGE)

    免疫原

    Recombinant Vaccinia virus containing the human CD105 cDNA.

    亚型

    IgG2a
  • 应用备注

    Flow cytometry: Recommended dilution: 1-5 μg/mL.
    Western blotting: Non-reducing conditions.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • Schmidt, Achermann, Odermatt, Breymann, Mol, Genoni, Zund, Hoerstrup: "Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source." in: Circulation, Vol. 116, Issue 11 Suppl, pp. I64-70, (2007) (PubMed).

  • 抗原

    Endoglin (ENG)

    别名

    CD105

    背景

    Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG, HHT1, ORW1

    基因ID

    2022

    UniProt

    P17813
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