PSMD10 抗体 (N-Term)
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Quick Overview for PSMD10 抗体 (N-Term) (ABIN928857)
抗原
See all PSMD10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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交叉反应
- 小鼠
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纯化方法
- Purified
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免疫原
- Psmd10 antibody was raised in rabbit using the N terminal of Psmd10 as the immunogen
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应用备注
- Optimal conditions should be determined by the investigator.
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说明
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Psmd10 Blocking Peptide, (ABIN939740), is also available for use as a blocking control in assays to test for specificity of this Psmd10 antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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浓度
- Lot specific
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缓冲液
- Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
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- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
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别名
- Psmd10
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背景
- Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Synonyms: Polyclonal Psmd10 antibody, Anti-Psmd10 antibody, proteasome, prosome, macropain 26S subunit, non-ATPase, 10 antibody, AW554874 antibody.
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway
抗原
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