GALR2 抗体 (C-Term)
Quick Overview for GALR2 抗体 (C-Term) (ABIN926733)
抗原
See all GALR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Purified
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免疫原
- GALR2 antibody was raised in rabbit using the C terminal of GALR2 as the immunogen
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应用备注
- Optimal conditions should be determined by the investigator.
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说明
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GALR2 Blocking Peptide, (ABIN936382), is also available for use as a blocking control in assays to test for specificity of this GALR2 antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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浓度
- Lot specific
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缓冲液
- Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
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- GALR2 (Galanin Receptor 2 (GALR2))
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别名
- GALR2
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背景
- Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. Synonyms: Polyclonal GALR2 antibody, Anti-GALR2 antibody, galanin receptor 2 antibody, GALNR2 antibody, MGC125983 antibody, MGC125984 antibody.
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途径
- cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour
抗原
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