TLR3 抗体
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北京 101111
Quick Overview for TLR3 抗体 (ABIN920707)
抗原
See all TLR3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Reacts with TLR3.
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过滤
- 0.2 μm filtered
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亚型
- IgG1
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应用备注
- Flow cytometry: (intracellular) Use at a 1:10 dilution. Western blot: Use at a 1:10 dilution.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 1 mL of 0.2 µm sterile filtered antibody solution at 100 µg/mL in PBS containing 0.1% protein stabilizer.
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储存条件
- 4 °C
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- TLR3 (Toll-Like Receptor 3 (TLR3))
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别名
- TLR3
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背景
- Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defence to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. In mammals, TLR identified as type I transmembrane signalling receptors with pattern recognition capabilies, have been implicated in the innate host defence to pathogens. As investigated so far all functional characterized TLR signal via the TLR/IL-1 receptor (IL-1R) pathway where recruitment of MyD88 seems to be essential. Viral replication within infected cells results in generation of dsRNA which can stimulate immune cells. Recent data show that TLR3 acts as a receptor involved in the recognition of dsRNA, indicating a role for TLR3 in viral recognition and innate defence.
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途径
- TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
抗原
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