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KDEL 抗体 (HRP)

Lys Asp Glu Leu 适用: 小鼠, 大鼠 IHC (p), ELISA, IHC (fro) 宿主: 兔 Polyclonal HRP
产品编号 ABIN903552
发货至: 中国
  • 抗原 See all KDEL (Lys Asp Glu Leu) products
    KDEL (Lys Asp Glu Leu)
    适用
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    小鼠, 大鼠
    宿主
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    克隆类型
    • 34
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    多克隆
    标记
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    This KDEL antibody is conjugated to HRP
    应用范围
    • 33
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    • 15
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    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    小鼠, 大鼠
    预测反应
    Human,Dog,Cow,Pig,Rabbit,Guinea Pig
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide KDEL
    亚型
    IgG
  • 应用备注
    IHC-P 1:200-400
    IHC-F 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    注意事项
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    KDEL (Lys Asp Glu Leu)
    Abstract
    Lys Asp Glu Leu 产品
    背景

    Synonyms: KDEL, Lys Asp Glu Leu antibody, GRP 78, GRP 94, KDEL1_HUMAN.

    Background: Endoplasmic reticulum Marker. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins (GRP 78) and GRP 94 respectively and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

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