电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

ISR-beta 抗体 (AA 1001-1100) (AbBy Fluor® 350)

This anti-ISR-beta antibody is a 兔 多克隆 antibody detecting ISR-beta in WB, FACS, IF (cc) 和 IF (p). Suitable for 人 和 大鼠.
产品编号 ABIN902826
发货至: 中国

Quick Overview for ISR-beta 抗体 (AA 1001-1100) (AbBy Fluor® 350) (ABIN902826)

抗原

See all ISR-beta 抗体
ISR-beta (Insulin Receptor beta (ISR-beta))

适用

  • 77
  • 71
  • 57
  • 3
  • 3
  • 3
  • 3
人, 大鼠

宿主

  • 75
  • 2

克隆类型

  • 75
  • 2
多克隆

标记

  • 11
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
This ISR-beta antibody is conjugated to AbBy Fluor® 350

应用范围

  • 58
  • 47
  • 38
  • 38
  • 16
  • 10
  • 10
  • 6
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 16
    • 16
    • 15
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1001-1100

    交叉反应

    人, 大鼠

    预测反应

    Mouse

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human IR beta

    亚型

    IgG
  • 应用备注

    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    ISR-beta (Insulin Receptor beta (ISR-beta))

    别名

    Insulin Receptor Beta

    背景

    Synonyms: CD 220, CD220, CD220 antigen, HHF 5, HHF5, HIR B, INSR, INSR, Insulin receptor, Insulin receptor subunit beta, IR, INSR_HUMAN.

    Background: The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.

    基因ID

    3643

    UniProt

    P06213
You are here:
Chat with us!