人 Papilloma Virus 33 E7 (HPV-33 E7) (AA 41-97) 抗体 (FITC)
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Quick Overview for 人 Papilloma Virus 33 E7 (HPV-33 E7) (AA 41-97) 抗体 (FITC) (ABIN901250)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 41-97
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特异性
- This antibody will also detect E7 in HPV58, but with slightly less affinity, due to a one amino acid change in the immunogen sequence range.
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交叉反应
- 人, Virus
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交叉反应 （详细）
- HPV33
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from HPV33 E7
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亚型
- IgG
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anti-Human Papilloma Virus 33 E7 (HPV-33 E7) (AA 41-97) antibody
HPV-33 E7 适用: 人, Human Papillomavirus (HPV), Virus IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Human Papilloma Virus 33 E7 (HPV-33 E7)
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别名
- HPV33 E7
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物质类
- Viral Protein
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背景
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Synonyms: E7 protein [Human papillomavirus type 33], Human Papilloma Virus, Human papillomavirus type 33, Human papillomavirus type 33, Protein 33, early protein E7 [Human papillomavirus type 33].
Background: E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
抗原
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