FOXO1 抗体 (AA 201-300) (AbBy Fluor® 647)
Quick Overview for FOXO1 抗体 (AA 201-300) (AbBy Fluor® 647) (ABIN897572)
抗原
See all FOXO1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 201-300
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FOXO1
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亚型
- IgG
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anti-Forkhead Box O1 (FOXO1) (AA 165-270) antibody
FOXO1 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 小鸡 WB, ELISA, IF (p), IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O1 (FOXO1) (AA 333-557) antibodyFOXO1 适用: 人 WB, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O1 (FOXO1) antibodyFOXO1 适用: 人, 小鼠 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Forkhead Box O1 (FOXO1) antibodyFOXO1 适用: 人 WB, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Forkhead Box O1 (FOXO1) antibodyFOXO1 适用: 人, 小鼠 WB, IHC, ELISA, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Forkhead Box O1 (FOXO1) (AA 556-655) antibodyFOXO1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4E9 unconjugated
anti-Forkhead Box O1 (FOXO1) (AA 452-555) antibodyFOXO1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A10 unconjugated
anti-Forkhead Box O1 (FOXO1) (pSer256) antibodyFOXO1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O1 (FOXO1) antibodyFOXO1 适用: 人, 小鼠 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Forkhead Box O1 (FOXO1) (AA 222-469) antibodyFOXO1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- FOXO1 (Forkhead Box O1 (FOXO1))
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别名
- Foxo1
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背景
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Synonyms: FKH1, FKHR, FOXO1A, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1
Background: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
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基因ID
- 2308
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UniProt
- Q12778
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途径
- PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
抗原
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