DEDD2 抗体 (AA 201-300) (Cy7)
Quick Overview for DEDD2 抗体 (AA 201-300) (Cy7) (ABIN893829)
抗原
See all DEDD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 201-300
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交叉反应
- 大鼠
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预测反应
- Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human DEDD2
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亚型
- IgG
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anti-Death Effector Domain Containing 2 (DEDD2) (AA 1-240) antibody
DEDD2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Death Effector Domain Containing 2 (DEDD2) (AA 162-193) antibodyDEDD2 适用: 人 WB 宿主: 兔 Polyclonal RB53921 unconjugated
anti-Death Effector Domain Containing 2 (DEDD2) (AA 43-75) antibodyDEDD2 适用: 人 WB 宿主: 兔 Polyclonal RB54369 unconjugated
anti-Death Effector Domain Containing 2 (DEDD2) (AA 179-228) antibodyDEDD2 适用: 人, 小鼠, 兔, Cow, 犬, 豚鼠, 马, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Death Effector Domain Containing 2 (DEDD2) (Middle Region) antibodyDEDD2 适用: 人, 大鼠, 小鼠, 兔, Cow, 犬, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- DEDD2 (Death Effector Domain Containing 2 (DEDD2))
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别名
- DEDD2
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背景
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Synonyms: Death effector domain containing 2, DED containing protein FLAME 3, DNA binding death effector domain containing protein 2, FADD like anti apoptotic molecule 3, FLAME 3,
Background: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
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基因ID
- 162989
抗原
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