Cullin 3 抗体 (AA 411-510) (AbBy Fluor® 647)
Quick Overview for Cullin 3 抗体 (AA 411-510) (AbBy Fluor® 647) (ABIN892711)
抗原
See all Cullin 3 (CUL3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 411-510
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特异性
- This antibody may detect Cullin-4 A/B
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交叉反应
- 人
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预测反应
- Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Cullin 3
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亚型
- IgG
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anti-Cullin 3 (CUL3) antibody
CUL3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Cullin 3 (CUL3) (AA 411-510) antibodyCUL3 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 3 (CUL3) antibodyCUL3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cullin 3 (CUL3) antibodyCUL3 适用: 人 IHC, ELISA 宿主: 兔 Monoclonal 7B6 unconjugated Recombinant Antibody
anti-Cullin 3 (CUL3) (AA 618-667) antibodyCUL3 适用: 人, 斑马鱼, Cow, 小鸡, 犬, 豚鼠, 马, 兔, 猴, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 3 (CUL3) (AA 301-400) antibodyCUL3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-Cullin 3 (CUL3) (N-Term) antibodyCUL3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cullin 3 (CUL3) antibodyCUL3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cullin 3 (CUL3) (N-Term) antibodyCUL3 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cullin 3 (CUL3) (Internal Region) antibodyVerified CUL3 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Cullin 3 (CUL3)
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别名
- Cullin 3
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背景
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Synonyms: CUL-3, PHA2E, Cullin-3, CUL3, KIAA0617
Background: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL, these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron, by mediating ubiquitination of WNK4. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539).
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基因ID
- 8452
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UniProt
- Q13618
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途径
- M Phase
抗原
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