ERAP1 抗体 (AA 651-730)
Quick Overview for ERAP1 抗体 (AA 651-730) (ABIN873313)
抗原
See all ERAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 651-730
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交叉反应
- 人
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预测反应
- Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human ARTS1
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亚型
- IgG
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))
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别名
- ARTS1
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背景
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Synonyms: Endoplasmic reticulum aminopeptidase 1, A LAP, A-LAP, Adipocyte derived leucine aminopeptidase, Adipocyte-derived leucine aminopeptidase, ALAP, Aminopeptidase PILS, APPILS, ARTS 1, ARTS-1, Arts1, Endoplasmic reticulum aminopeptidase 1, ERAAP, ERAP 1, Erap1, ERAP1_HUMAN, PILS AP, PILS-AP, PILSA, PILSAP, Puromycin insensitive leucyl specic aminopeptidase, Puromycin-insensitive leucyl-specic aminopeptidase, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, VEGF-induced aminopeptidase.
Background: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
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基因ID
- 51752
抗原
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