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HNE 抗体

Name: HNE 抗体
SKU: ABIN873270
Availability: OutOfStock

This anti-HNE antibody is a 兔多克隆 antibody detecting HNE in WB, ELISA, IF (p), IHC (fro) 和 IHC (p). Suitable for . This Primary Antibody has been cited in 13+ publications.

The diabetes effect on IR affected cardiac lipid peroxidation in MDA content (A, n = 6), 4-HNE expression (B, n = 3), leukocyte infiltration and cardiac structure (C,D, n = 5), microcirculation (E,F, n = 10) and infarct size (G,H, n = 5) in IR CON and IR STZ rats. (HNE 抗体)

Formalin-fixed and paraffin embedded mouse pancreas labeled with Anti-4 Hydroxynonenal Polyclonal Antibody, Unconjugated (ABIN873270) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (HNE 抗体)

IHC

Antigen: 2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000; TMB staining Read the data in Microplate Reader by 450nm. (HNE 抗体)

ELISA

Formalin-fixed and paraffin embedded mouse pancreas labeled with Anti-4 Hydroxynonenal Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining. (HNE 抗体)

IHC (p)

ELISA

Mesenteric vascular Western blot graph (A) and analysis of 4-HNE (B), CaSR (C), p-eNOS (D) and BAG3 (E) are demonstrated. (HNE 抗体)

6 images

(13 references)

产品编号 ABIN873270

发货至: 中国

Quick Overview for HNE 抗体 (ABIN873270)

抗原

See all HNE 抗体

HNE (4-Hydroxynonenal (HNE))

适用

请咨询

宿主

兔

克隆类型

多克隆

标记

This HNE antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

交叉反应

猴, 小鼠, 大鼠

交叉反应（详细）

4-Hydroxynonenal

纯化方法

Purified by Protein A.

免疫原

4 Hydroxynonenal conjugated to BSA

亚型

IgG
anti-4-Hydroxynonenal (HNE) antibody
HNE WB, ELISA, IHC 宿主: 小鼠 Monoclonal HNEJ-2 unconjugated

anti-4-Hydroxynonenal (HNE) antibody
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 unconjugated

anti-4-Hydroxynonenal (HNE) antibody (HRP)
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 HRP

anti-4-Hydroxynonenal (HNE) antibody (FITC)
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 FITC

anti-4-Hydroxynonenal (HNE) antibody (Biotin)
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 Biotin

anti-4-Hydroxynonenal (HNE) antibody (PE)
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 PE

anti-4-Hydroxynonenal (HNE) antibody (PerCP)
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 PerCP

anti-4-Hydroxynonenal (HNE) antibody (APC)
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 APC

anti-4-Hydroxynonenal (HNE) antibody (Atto 594)
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 Atto 594

anti-4-Hydroxynonenal (HNE) antibody (Atto 488)
HNE WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal 12F7 Atto 488

应用备注

IHC-P 1:100-500
IF(IHC-P) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Shin, Lee, Jang, Kim, Park, Kang, Shim, Ko, Hwang: "Hemolysis-induced hepatic ferroptosis following xenotransfusion of genetically modified pig red blood cells." in: Scientific reports, Vol. 15, Issue 1, pp. 44014, (2025) (PubMed).

Zhang, Chang, Chen, Beg, Huang, Vick, Wang, Zhang, Yttre, Gupta, Castleberry, Zhang, Dai, Zhu, Song, Yang, Brown, Xu, Ma, Smith, Zielonka, Traylor, Ben Dhaou, Orr, Cui, Chen: "Oxidized LDL stimulates PKM2-mediated mtROS production and phagocytosis." in: Journal of lipid research, Vol. 66, Issue 5, pp. 100809, (2025) (PubMed).

Târtea, Popa-Wagner, Sfredel, Mitran, Dan, Țucă, Preda, Raicea, Țieranu, Cozma, Vătășescu: "Chitosan Versus Dapagliflozin in a Diabetic Cardiomyopathy Mouse Model." in: International journal of molecular sciences, Vol. 25, Issue 4, (2024) (PubMed).

Zhang, Chang, Chen, Beg, Huang, Vick, Wang, Zhang, Yttre, Gupta, Castleberry, Zhang, Dai, Song, Zhu, Yang, Brown, Xu, Ma, Smith, Zielonka, Traylor, Dhaou, Orr, Cui, Zheng, Chen: "Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway." in: bioRxiv : the preprint server for biology, (2024) (PubMed).

Chien, Wen, Cheng, Tsai, Chiang, Chien: "Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats." in: Antioxidants (Basel, Switzerland), Vol. 9, Issue 8, (2020) (PubMed).

Vairappan, Sundhar, Srinivas: "Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CCl4-Induced Cirrhotic Mice." in: Molecular neurobiology, Vol. 56, Issue 7, pp. 4718-4729, (2019) (PubMed).

Sapkota, Gaire, Cho, Jeon, Kwon, Jang, Kim, Ryu, Choi: "Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation." in: PLoS ONE, Vol. 12, Issue 2, pp. e0171479, (2017) (PubMed).

Kagaya, Sasaki, Kino, Taniguchi, Kuraishi, Andoh: "Involvement of oxidative stress in increased peripheral nerve firing during spontaneous dysesthesia in a mouse model of ischemia-reperfusion." in: Neuroscience letters, Vol. 631, pp. 109-14, (2016) (PubMed).

Zhang, Song, Pang, Zhang, Wan, Yuan, Wu, Liu: "Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice." in: World journal of gastroenterology : WJG, Vol. 21, Issue 14, pp. 4195-209, (2015) (PubMed).

Polverino, Doyle-Eisele, McDonald, Wilder, Royer, Laucho-Contreras, Kelly, Divo, Pinto-Plata, Mauderly, Celli, Tesfaigzi, Owen: "A novel nonhuman primate model of cigarette smoke-induced airway disease." in: The American journal of pathology, Vol. 185, Issue 3, pp. 741-55, (2015) (PubMed).

Duong, Chami, McMahon, Fong, Dennis, Freedman, Witting: "Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury." in: Journal of neurochemistry, Vol. 130, Issue 6, pp. 733-47, (2014) (PubMed).

Haberman, Tickle, Dexheimer, Kim, Tang, Karns, Baldassano, Noe, Rosh, Markowitz, Heyman, Griffiths, Crandall, Mack, Baker, Huttenhower, Keljo, Hyams, Kugathasan, Walters, Aronow, Xavier, Gevers et al.: "Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. ..." in: The Journal of clinical investigation, Vol. 124, Issue 8, pp. 3617-33, (2014) (PubMed).

Guo, Tong, Xi, Yang, Dong, Wen: "Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats." in: Journal of ethnopharmacology, Vol. 144, Issue 3, pp. 768-74, (2012) (PubMed).
抗原

HNE (4-Hydroxynonenal (HNE))

别名

4 Hydroxynonenal

物质类

Chemical

背景

Synonyms: 4-Hydroxy-2-Nonenal, 4Hydroxynonenal, 4-Hydroxynonenal, 4 HNE, 4HNE, 4-HNE, E-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA.
Background: Aldehydic products of lipid peroxidation, such as 4 hydroxynonenal (4 HNE), have been implicated in the etiology of pathological changes under oxidative stress as a key mediator of oxidative stress induced cell death. It is a stable product of lipid peroxidation, is proarrhythmic and may contribute to the cytotoxic effects of oxidative stress 4-HNE has been hypothesized to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.

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HNE 抗体

Quick Overview for HNE 抗体 (ABIN873270)

抗原

适用

宿主

克隆类型

标记

应用范围

HNE抗体详情

交叉反应

交叉反应（详细）

纯化方法

免疫原

亚型

Alternatives

使用细节

应用备注

限制

贮存及处理

状态

浓度

缓冲液

储存液

注意事项

储存条件

储存方法

有效期

References for anti-HNE antibody (ABIN873270)

HNE目标详情

抗原

别名

物质类

背景

HNE 抗体

Quick Overview for HNE 抗体 (ABIN873270)

抗原

适用

宿主

克隆类型

标记

应用范围

HNE抗体详情

交叉反应

交叉反应 （详细）

纯化方法

免疫原

亚型

Alternatives

使用细节

应用备注

限制

贮存及处理

状态

浓度

缓冲液

储存液

注意事项

储存条件

储存方法

有效期

References for anti-HNE antibody (ABIN873270)

HNE目标详情

抗原

别名

物质类

背景

交叉反应（详细）