NET1 抗体 (AA 501-596)
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北京 101111
Quick Overview for NET1 抗体 (AA 501-596) (ABIN873108)
抗原
See all NET1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-596
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交叉反应
- 人, 小鼠
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预测反应
- Rat,Dog,Cow,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human NET1
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亚型
- IgG
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anti-Neuroepithelial Cell Transforming 1 (NET1) (C-Term) antibody
Verified NET1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Neuroepithelial Cell Transforming 1 (NET1) (C-Term) antibodyNET1 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuroepithelial Cell Transforming 1 (NET1) (AA 1-542) antibodyNET1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Neuroepithelial Cell Transforming 1 (NET1) (AA 356-385) antibodyNET1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB30330 unconjugated
anti-Neuroepithelial Cell Transforming 1 (NET1) antibodyNET1 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroepithelial Cell Transforming 1 (NET1) antibodyNET1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Neuroepithelial Cell Transforming 1 (NET1) (AA 288-337) antibodyNET1 适用: 人, 小鼠, Cow, 斑马鱼, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuroepithelial Cell Transforming 1 (NET1) (AA 72-121) antibodyNET1 适用: 人, 大鼠, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuroepithelial Cell Transforming 1 (NET1) (AA 1-542) antibodyNET1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- NET1 (Neuroepithelial Cell Transforming 1 (NET1))
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别名
- Net1
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背景
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Synonyms: NAT1, NET, NET, NET1, Norepinephrine transporter, SLC6A2, SLC6A5, SLC6A5, Sodium dependent noradrenaline transporter, Solute carrier family 6 neurotransmitter transporter norepinephrine member 5, Solute carrier family 6 member 2, Solute carrier family 6 member 2.
Background: Catecholamine, a term used for the hormone adrenaline and its sequentially hydroxylated form noradrenaline, is involved in fight or flight responses. Noradrenaline is released from the post ganglionic sympathetic nerve endings and exerts its effects locally in the immediate vicinity of its release. In the CNS, noradrenaline is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors, and control of the endocrine and autonomic nervous systems. Peripherally, noradrenaline is present in sympathetic nerve endings and has full control of the sympathetic nervous system. Noradrenaline released from pre-synaptic nerve terminals is reabsorbed (70-90 % ) by noradrenaline transporters and its biological effects are terminated. The noradrenaline transport via noradrenaline transporters is an active, Na+/Cl- dependent transport process mediated by noradrenaline transporters. Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, are targets for multiple antidepressants and psychostimulants, and are deficient in affective and autonomic disorders. In rat brain, noradrenaline transporter is expressed in noradrenergic neuronal somata, axons and dendrites, and hippocampus and cortex, but is absent from epinephrine- and dopamine-containing neurons. At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake and concentrations in cerebrospinal fluid in humans. The association between these genetic variations in noradrenaline transporters and several psychiatric and cardiovascular disorders is just emerging. Recently, a single amino acid mutation (hNET-A457P) showed deficiency in noradrenaline transport in an orthostatic intolerance patient.
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基因ID
- 10276
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途径
- Neurotrophin Signaling Pathway
抗原
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