NLRP4 抗体 (AA 351-450)
Quick Overview for NLRP4 抗体 (AA 351-450) (ABIN872353)
抗原
See all NLRP4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 351-450
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特异性
- This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human NALP4
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亚型
- IgG
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anti-NLR Family, Pyrin Domain Containing 4 (NLRP4) (AA 121-149) antibody
NLRP4 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
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别名
- NALP4
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背景
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Synonyms: NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, RNH2
Background: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
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基因ID
- 147945
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UniProt
- Q96MN2
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途径
- Inflammasome
抗原
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