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CDK5 抗体 (pTyr15)

CDK5 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN872301
发货至: 中国
  • 抗原 See all CDK5 抗体
    CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
    抗原表位
    • 29
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    pTyr15
    适用
    • 124
    • 100
    • 97
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    • 9
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    小鼠, 大鼠
    宿主
    • 111
    • 28
    克隆类型
    • 112
    • 27
    多克隆
    标记
    • 70
    • 8
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    This CDK5 antibody is un-conjugated
    应用范围
    • 118
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    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    小鼠, 大鼠
    预测反应
    Cow,Horse,Chicken,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic phosphopeptide derived from human CDK5 around the phosphorylation site of Tyr15
    亚型
    IgG
    Top Product
    Discover our top product CDK5 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • Yin, Qi, Ren, Wang, Jiang, Feng, Cui: "Roscovitine treatment caused impairment of fertilizing ability in mice." in: Toxicology letters, Vol. 237, Issue 3, pp. 200-9, (2015) (PubMed).

  • 抗原
    CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
    别名
    CDK5 (CDK5 产品)
    别名
    PSSALRE antibody, AW048668 antibody, Crk6 antibody, CDK5 antibody, CG8203 antibody, DmCdk5 antibody, Dmel\\CG8203 antibody, cdk5 antibody, zgc:101604 antibody, cyclin dependent kinase 5 antibody, cyclin-dependent kinase 5 antibody, Cyclin-dependent kinase 5 antibody, cyclin-dependent kinase 5 L homeolog antibody, Cyclin-dependent-like kinase 5 antibody, CDK5 antibody, Cdk5 antibody, cdk5 antibody, cdk5.L antibody, cdk-5 antibody
    背景

    Synonyms: Cdk5 phospho Y15, p-Cdk5Y15, Cdk 5, Cell division protein kinase 5, Crk6, Cyclin dependent kinase 5, Protein kinase CDK5 splicing, PSSALRE, Serine threonine protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5_HUMAN.

    Background: CDK5 (Cyclin Dependent Kinase 5) is serine/threonine kinase involved in synaptic regulation and neuronal development, phosphorylates synaptic protein Pctaire1, regulates acetylcholine receptor expression. CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.

    基因ID
    1020
    途径
    Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
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