CD22 抗体 (AA 839-843)
Our Local Distributor
北京 101111
Quick Overview for CD22 抗体 (AA 839-843) (ABIN871688)
抗原
See all CD22 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 839-843
-
特异性
- The antibody detects endogenous level of total CD22 protein.
-
纯化方法
- Affinity purified
-
免疫原
- Peptide sequence around AA 839-843 (N-V-D-Y-V) derived from Human CD22. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
-
-
-
-
应用备注
- Western blotting: 1:500-1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
-
-
- CD22 (CD22 Molecule (CD22))
-
别名
- CD22
-
背景
- Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to a-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
-
分子量
- 140 kDa
-
基因ID
- 933
-
NCBI登录号
- NP_001762
-
UniProt
- P20273
抗原
-