tau 抗体 (pSer416)
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北京 101111
Quick Overview for tau 抗体 (pSer416) (ABIN871413)
抗原
See all tau 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer416
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特异性
- The antibody detects endogenous levels of Tau only when phosphorylated at serine 416.
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纯化方法
- Affinity purified
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免疫原
- Peptide sequence around phosphorylation site of pSer416 (T-G-S (p) -I-D) derived from Rat Tau. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
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anti-tau Protein (pSer396) antibody
适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-tau Protein (AA 677-707), (C-Term) antibody适用: 人, 小鼠, 大鼠, Cynomolgus WB, IF, IHC (p) 宿主: 兔 Polyclonal RB2883 unconjugated
anti-tau Protein (AA 677-707) antibody适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-tau Protein antibody适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 12F4 unconjugated
anti-tau Protein (AA 681-758) antibody适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-tau Protein antibody (PerCP)适用: 人 WB, ELISA, IF, ICC, DB 宿主: 小鼠 Monoclonal 1D5 PerCP
anti-tau Protein antibody (PE)适用: 人 WB, ELISA, IF, ICC, DB 宿主: 小鼠 Monoclonal 1D5 PE
anti-tau Protein (pSer202), (pThr205) antibody (Atto 390)适用: 人 WB, ELISA, IHC, IF, ICC, DB 宿主: 兔 Monoclonal AH36 Atto 390
anti-tau Protein (pSer202), (pThr205) antibody (Atto 594)适用: 人 WB, ELISA, IHC, IF, ICC, DB 宿主: 兔 Monoclonal AH36 Atto 594
anti-tau Protein (pSer202), (pThr205) antibody (APC)适用: 人 WB, ELISA, IHC, IF, ICC, DB 宿主: 兔 Monoclonal AH36 APC
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应用备注
- Western blotting: 1:500-1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- tau (tau Protein)
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别名
- Tau
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背景
- Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies
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分子量
- 78 kDa
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基因ID
- 29477
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NCBI登录号
- NP_058908
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UniProt
- P19332
抗原
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