ALDH1A1 抗体
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北京 101111
Quick Overview for ALDH1A1 抗体 (ABIN865528)
抗原
See all ALDH1A1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human ALDH1A1 expressed in E. Coli.
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亚型
- IgG1
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应用备注
- WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ELISA: Propose dilution 1/10000.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100g/100l
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- ALDH1A1 (Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1))
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别名
- ALDH1A1
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背景
- ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros. ALDH1A1 is also of interest in Parkinson's Disease (PD) being expressed in the the A9 dopaminergic (DA) neuronal group projecting to the dorsal striatum, this is the most vulnerable site in PD (Chung et al, 2005). ALDH1A1 protein is a known mesencephalic dopaminergic marker. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid .ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea . Synonyms: ALDC, ALDH1, PUMB1, ALDH11, RALDH1, ALDH-E1, MGC2318, ALDH1A1
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分子量
- 55kDa
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基因ID
- 216
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途径
- Dopaminergic Neurogenesis
抗原
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