CRTC2 抗体
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- 抗原 See all CRTC2 抗体
- CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
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适用
- 人, 猴
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CRTC2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
- 纯化方法
- Ascitic fluid
- 免疫原
- Purified recombinant fragment of human CRTC2 expressed in E. Coli.
- 克隆位点
- 5B10
- 亚型
- IgG1
- Top Product
- Discover our top product CRTC2 Primary Antibody
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anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (C-Term) antibody
Verified CRTC2 适用: 人, 大鼠 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) antibodyCRTC2 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5B10 unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (pSer171) antibodyCRTC2 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 595-693) antibodyCRTC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E6 unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 180-372) antibodyCRTC2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 83-96) antibodyVerified CRTC2 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 595-693) antibodyCRTC2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 542-553) antibodyVerified CRTC2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- WB:1/500 - 1/2000,IHC:1/200 - 1/1000,IF:1/200-1/1000,FC:1/200-1/400, ELISA: Propose dilution 1/10000.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 100g/100l
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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- 抗原
- CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
- 别名
- CRTC2 (CRTC2 产品)
- 背景
- Glucose homeostasis is regulated by hormones and cellular energy status. Elevations of blood glucose during feeding stimulate insulin release from pancreatic -cells through a glucose sensing pathway. Feeding also stimulates release of gut hormones such as glucagon-like peptide-1 (GLP-1), which further induces insulin release, inhibits glucagon release and promotes -cell viability. CREB-dependent transcription likely plays a role in both glucose sensing and GLP-1 signaling . The protein Torc2 (transducer of regulated CREB activity 2) functions as a CREB co-activator and is implicated in mediating the effects of these two pathways . In quiescent cells, Torc2 is phosphorylated at Ser171 and becomes sequestered in the cytoplasm via an interaction with 14-3-3 proteins. Glucose and gut hormones lead to the dephosphorylation of Torc2 and its dissociation from 14-3-3 proteins. Dephosphorylated Torc2 enters the nucleus to promote CREB-dependent transcription. Synonyms: TORC2, TORC-2, CRTC2
- 分子量
- 80kDa
- 基因ID
- 200186
- 途径
- AMPK Signaling, Carbohydrate Homeostasis
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