B-Cell Linker 抗体
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北京 101111
Quick Overview for B-Cell Linker 抗体 (ABIN865398)
抗原
See all B-Cell Linker (BLNK) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human BLNK expressed in E. Coli.
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亚型
- IgG1
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应用备注
- WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100g/100l
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- B-Cell Linker (BLNK)
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别名
- BLNK
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背景
- This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Synonyms: AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051
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分子量
- 68kDa
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基因ID
- 29760
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途径
- BCR Signaling
抗原
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