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B-Cell Linker 抗体

This anti-B-Cell Linker antibody is a 小鼠 单克隆 antibody detecting B-Cell Linker in WB, ELISA, IHC, FACS 和 IF. Suitable for 人 和 小鼠.
产品编号 ABIN865398
发货至: 中国

Quick Overview for B-Cell Linker 抗体 (ABIN865398)

抗原

See all B-Cell Linker (BLNK) 抗体
B-Cell Linker (BLNK)

适用

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人, 小鼠

宿主

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  • 1
小鼠

克隆类型

  • 111
  • 10
单克隆

标记

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This B-Cell Linker antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

克隆位点

5G9
  • 纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human BLNK expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    100g/100l

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • 抗原

    B-Cell Linker (BLNK)

    别名

    BLNK

    背景

    This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Synonyms: AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051

    分子量

    68kDa

    基因ID

    29760

    途径

    BCR Signaling
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