SHANK1 抗体 (AA 469-691)
Quick Overview for SHANK1 抗体 (AA 469-691) (ABIN863122)
抗原
See all SHANK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 469-691
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特异性
- Detects ~190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Protein G Purified
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免疫原
- Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1
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亚型
- IgG1
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anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (HRP)
SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) HRP
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (FITC)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) FITC
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Biotin)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Biotin
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (PE)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) PE
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (APC)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) APC
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (PerCP)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) PerCP
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 488)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 488
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 594)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 594
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 390)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 390
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 2088-2161) antibodySHANK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8F7 unconjugated
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应用备注
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- WB (1:1000)
- IHC (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
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说明
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1 μg/ml of ABIN863122 was sufficient for detection of Shank1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C
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- SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))
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别名
- SHANK1
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背景
- Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
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基因ID
- 78957
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NCBI登录号
- NP_113939
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UniProt
- Q9WV48
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途径
- Synaptic Membrane, Maintenance of Protein Location
抗原
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