ISR-beta 抗体 (pTyr1185) (Biotin)
Quick Overview for ISR-beta 抗体 (pTyr1185) (Biotin) (ABIN802295)
抗原
See all ISR-beta 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr1185
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human INSR around the phosphorylation site of Tyr1185 [DI(p-Y)ET]
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亚型
- IgG
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anti-Insulin Receptor beta (ISR-beta) (AA 801-900) antibody
ISR-beta 适用: 人, 大鼠, 小鼠 FACS, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor beta (ISR-beta) (AA 1001-1100) antibodyISR-beta 适用: 人, 大鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor beta (ISR-beta) (pTyr1185) antibodyISR-beta 适用: 人, 大鼠, 小鼠 WB, IF (cc), IF (p), ELISA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor beta (ISR-beta) (pTyr1355) antibodyISR-beta 适用: 人, 大鼠, 小鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- ISR-beta (Insulin Receptor beta (ISR-beta))
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别名
- Insulin Receptor Beta
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背景
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Synonyms: HHF5, CD22, Insulin receptor, IR, INSR
Background: The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
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基因ID
- 3643
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UniProt
- P06213
抗原
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