TRF1 抗体
Quick Overview for TRF1 抗体 (ABIN790393)
抗原
See all TRF1 (TERF1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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品牌
- IHC-plus™
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特异性
- Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.
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纯化方法
- Affinity purified
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免疫原
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Recombinant TRF1
Type of Immunogen: Recombinant protein -
亚型
- IgG1
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anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 148-428) antibody
TERF1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 240-419) antibodyTERF1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 260-439) antibodyTERF1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 1-439) antibodyTERF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (pSer219) antibodyTERF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 260-439) antibodyTERF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (C-Term) antibodyTERF1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (pSer219) antibodyTERF1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (C-Term) antibodyVerified TERF1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Approved: ELISA, IHC, IHC-Fr, IHC-P (10 μg/mL)
Usage: Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose Histology Positive Control Tissue: Human tonsil. -
说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS containing 0.09 % sodium azide. Sourced in TCS.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- avoid freeze thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
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- TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))
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别名
- TRF1 / TERF1
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背景
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Name/Gene ID: TERF1
Synonyms: TERF1, HTRF1-AS, NIMA-interacting protein 2, PIN2, Telomeric protein Pin2/TRF1, TRBF1, TTAGGG repeat-binding factor 1, T-TRF1, TRF, TRF1 -
基因ID
- 7013
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途径
- Cell Division Cycle, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
抗原
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