GRIN2C 抗体 (pSer1244)
Our Local Distributor
北京 101111
Quick Overview for GRIN2C 抗体 (pSer1244) (ABIN784608)
抗原
See all GRIN2C 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pSer1244
-
特异性
- Specific for the ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1244. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to generate the antibody but not by the corresponding dephospho-peptide.
-
交叉反应 （详细）
-
Species reactivity (expected):Bovine, Canine, Human and non-Human primates.
Species reactivity (tested):Mouse and Rat. -
纯化方法
- Affinity Chromatography.
-
免疫原
- Synthetic phospho-peptide surrounding the phospho Ser1244 of the NR2C-subunit of Rat NMDA receptor.
-
亚型
- IgG
-
-
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 908-1007) antibody
GRIN2C 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) antibodyGRIN2C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 69-118) antibodyGRIN2C 适用: 人, 小鼠, 大鼠, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 1-171) antibodyGRIN2C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 365-377), (Extracellular) antibodyGRIN2C 适用: 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 1-171) antibodyGRIN2C 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (pSer1096) antibodyGRIN2C 适用: 人, 小鼠, 大鼠, Cow, 犬, 灵长类 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (pSer1244) antibodyGRIN2C 适用: 人, 小鼠, 大鼠, Cow, 犬, 灵长类 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (N-Term) antibodyGRIN2C 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 567-595) antibodyGRIN2C 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40514 unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
储存方法
- Store the antibody undiluted (in aliquots) at -20 °C.
-
-
- GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))
-
别名
- NMDA Receptor 2C
-
背景
- The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Phosphorylation of Ser1244 has been shown to regulate NMDA receptor channel function (Chen et al., 2006).Synonyms: GRIN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C
-
基因ID
- 24411
-
NCBI登录号
- NP_036707
-
途径
- Synaptic Membrane
抗原
-
