ASAH1 抗体 (C-Term)
Quick Overview for ASAH1 抗体 (C-Term) (ABIN783822)
抗原
See all ASAH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects Acid ceramidase at C-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse, Rat.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 16 amino acid peptide near the carboxy terminus of the Human ASAH1
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anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 144-395) antibody
ASAH1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 25-124) antibodyASAH1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 146-395) antibodyASAH1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 25-125) antibodyASAH1 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 25-125) antibodyASAH1 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 22-395) antibodyASAH1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 146-395) antibodyASAH1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 1-395) antibodyASAH1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (N-Term) antibodyASAH1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Bat, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 140-389) antibodyASAH1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % Sodium Azide as presrevative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C up to three months or (in aliquots) at -20 °C for longer.
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- ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
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别名
- Acid Ceramidase
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背景
- Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.Synonyms: ASAH, ASAH1, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase, PHP32, Putative 32 kDa heart protein
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基因ID
- 427
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NCBI登录号
- NP_001120977
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UniProt
- Q13510
抗原
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